![]() Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. SPECIFICATIONS Dimensions W: 3 1/2' L: 4 Ft5 Ft6 Ft7 Ft 8 FtRun length (Ft) H: 3 3/4' Light Source LED CCT/Color Tunable White CRI 80 90 Watt (Approx) 3.7 W/Ft5.7 W/Ft7.6 W/Ft9. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. We feel fortunate to be a part of the Cream Ridge community and the many amenities it has to offer. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. ![]() Biologically Interesting Molecule Reference Dictionary (BIRD).
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